Read e-book online Adult Epilepsy PDF

By Gregory D. Cascino, Joseph I. Sirven

Designed to supply a entire yet obtainable advent to epilepsy and seizure issues, grownup Epilepsy presents cutting-edge details in a concise structure invaluable to a large viewers, from neurology citizens to epilepsy fellows and practitioners. This illustrated consultant to the review, prognosis, and remedy of epilepsy is a invaluable source permitting clinicians to stick on most sensible of the most recent techniques for top perform.

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8 patient-years of follow-up, none of these patients subsequently had seizures. These findings emphasize that the presence of IEDs on routine EEG recordings should be interpreted in the context of the clinical history, especially for patients with neurological disorders, structural lesions, or previous craniotomy [6, 47]. In general, the clinical usefulness of a diagnostic test depends on the disease prevalence in the population under consideration. For example, if 55% of patients with epilepsy have IEDs and 4% of patients without epilepsy have IEDs, then the positive predictive value of IEDs for the diagnosis of epilepsy does not exceed 80% until the prevalence of epilepsy in the population tested is greater than 20% [4, 5].

The incidence of acute symptomatic seizures tends to be higher in men than in women [22]. Just like epilepsy, the age-specific incidence of acute symptomatic seizures is highest during the first year of life. This is attributed to the high incidence of acute symptomatic seizures associated with metabolic, infectious, and encephalopathic causes during the neonatal and perinatal periods. Incidence declines in childhood and early adult years and reaches a nadir among those between the ages of 25–34 years of age [22].

Given that the diagnosis of Alzheimer’s disease is confirmed only by autopsy, makes it difficult to establish whether some patients may have concurrent epilepsy because of the overlapping similar presentations. One study found a 10-fold increased risk for unprovoked seizures in Alzheimer’s disease [22]. Another reported new onset seizures developed in 16% of patients with probable Alzheimer’s disease after they became severely demented [23]. Moreover, a Class I study of geriatric epilepsy in a veterans population found that neurodegenerative conditions accounted for almost 11% of epilepsy disorders in this group [26].

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