Download PDF by Scott A. Snyder, Erick M. Carreira, Carl P. Decicco, Alois: Applications of Domino Transformations in Organic Synthesis,

By Scott A. Snyder, Erick M. Carreira, Carl P. Decicco, Alois Fürstner, Guido Koch, Gary A. Molander, Ernst Schaumann

The quick speed of evolution in domino, or cascade-based ameliorations has revolutionized the perform of chemical synthesis for the construction of ordinary items, designed molecules, and pharmaceuticals.


"Science of Synthesis: functions of Domino alterations in natural Synthesis" explores the subject completely and systematically, serving because the foundation for sensible purposes and destiny study. The 2-volume set offers the state-of-the-art by way of layout, procedure, and experimental techniques, resulting in a number of occasions being entire inside of a unmarried response vessel. The content material is geared up by way of the middle form of response used to start up the development, be it a pericyclic response, a metal-mediated transformation, radical chemistry, or an acid-induced cascade between many others.


Volume 1 covers polyene/cation-pi cyclizations, metathesis, radical, and metal-mediated reactions, and non-radical skeletal rearrangements.

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Extra info for Applications of Domino Transformations in Organic Synthesis, Volume 1

Example text

4 Rare Earth Metal Mediated Domino Reactions T. 4 Rare Earth Metal Mediated Domino Reactions . . . . . . . . . . . . . . 1 Addition to C=O or C=C-C=O as a Primary Step . . . . . . . . . . . . . 1 Aldol-Type Reactions . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1,4-Addition Reactions . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Addition to C=N or C=C-C=N as a Primary Step . . . . . . . . .

1 Domino Reactions with Transition-Metal Catalysts . . . . . . . . . . . . . 5 Cobalt and Other Metal Mediated Domino Reactions: The Pauson–Khand Reaction and Its Use in Natural Product Total Synthesis L. Shi and Z. 1 Enyne-Based Pauson–Khand Reactions . . . . . . . . . . . . . . . . . . . 1 A Short Synthesis of Racemic 13-Deoxyserratine . . . . . . . . . . . . . . 2 Total Synthesis of Paecilomycine A . . . . . . . . . . . . . . .

3 1,4-Brook Rearrangement . . . . . . . . . . . . . . . . . . . . . . . . . 1 1,4-Brook Rearrangement of Silyl-Substituted Carbanions with Epoxides . . . 2 1,4-Brook Rearrangement with Dihalosilyl-Substituted Methyllithium . . . . 3 1,4-Brook Rearrangement with Allylsilanes . . . . . . . . . . . . . . . . . 4 1,4-Brook Rearrangement with Silylated Benzaldehydes . . . . . . . . . . 5 1,4-Brook Rearrangement with Vinylsilanes .

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