By R. Morrin Acheson
The Chemistry of Heterocyclic Compounds, in view that its inception, has been well-known as a cornerstone of heterocyclic chemistry. each one quantity makes an attempt to debate all elements – homes, synthesis, reactions, physiological and business importance – of a selected ring approach. to maintain the sequence updated, supplementary volumes overlaying the hot literature on every one person ring method were released. Many ring structures (such as pyridines and oxazoles) are taken care of in specific books, every one along with separate volumes or components facing diverse person subject matters. With all authors are well-known specialists, the Chemistry of Heterocyclic Chemistry is taken into account around the world because the critical source for natural, bioorganic, and medicinal chemists.
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Extra resources for The Chemistry of Heterocyclic Compounds, Acridines
G* 3. General Properties of Acridine Acridine itself, although the parent compound of many useful and widely differing substances, is of comparatively little importance. 6e 3. General Properties of Acridine 59 Acridine is a very pale yellow solid that sublimes at ca. looo, boils2 a t 345-346"/760 mm, and crystallizes well from ethanol or benzene. It dissolves in approximately 6 parts by weight of ethanol, 5 parts of benzene, and 16 parts of ether. 2 It is slightly soluble in both liquid ammonia and liquid sulfur Five polymorphic forms of acridine are known.
Despite the difficultiesthat surround the interpretation of various fluorescences, it has been possible to use a number of acridines as fluorescent indicators. (See Refs. ) Certain acridine derivatives have been identified by means of their. 337 eV was obtained. 5 x 10la ohm-cm. 280 Potentiometric titration (see also Chapter 11, p. 3)281was taken for the pK, of acridine, in the latter instance. 286The studies of Reynaud have shown that the pK value for acridine is more sensitive to solvent effects than that of quinoline or p ~ r i d i n e .
When mixtures of rn-diamines are used, the product is almost invariably a mixture of the two symmetrical cyclization products, the asymmetric product being formed, if at all, in small yield. I6@ Carbon monoxide reacts with m-phenylenediamine at about 3000 atm pressure t o give a brown powder that may be a polymeric 3,6-diaminoacridine derivative. 166 (2) 3-Aminoacridines When 3-aminodiphenylamine (N-phenyl-m-phenylenediamine) (30) was used in the formic acid synthesis,I6"some 3-aminoacridine (33) was formed, as well as the normal product, 3,6-bisphenylaminoacridine (31).